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In the modern analyze, we reported the identification along with the characterization of a whole new atypical opioid receptor with exclusive adverse regulatory Attributes toward opioid peptides.1 Our final results confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-spectrum sca
Gene expression analysis disclosed that ACKR3 is very expressed in a number of brain locations equivalent to crucial opioid action centers. In addition, its expression stages are sometimes bigger than These of classical opioid receptors, which even more supports the physiological relevance of its observed in vitro opioid peptide scavenging potentia